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Insulin signaling regulates the FoxM1/PLK1/CENP-A pathway to promote adaptive β-cell proliferation. Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A and Kulkarni RN. Cell Metabolism, Mar 2017.
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Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function. Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O’Neill BT and Kahn CR. Diabetes, Aug 2016.
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Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS and Maratos-Flier E. PLoS One, Feb 2016.
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SerpinB1 Promotes Pancreatic β Cell Proliferation. El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O’Donnell E and Kulkarni RN. Cell Metabolism, Jan 2016.
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Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL and Kulkarni RN. Cell Metabolism, Aug 2015.
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Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG 2nd, Smith RD, Qian WJ and Kulkarni RN. Journal of Proteome Research, Aug 2015.
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The Polycomb protein, Bmi1, regulates insulin sensitivity. Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ and Stoffers DA. Molecular Metabolism, Aug 2014.
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Soluble factors secreted by T cells promote β-cell proliferation. Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D and Kulkarni RN. Diabetes, Jan 2014.
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Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Ræder H, McAllister FE, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder MB, Immervoll H, Hoem D, Dimcevski G, Njølstad PR, Molven A, Gygi SP and Kulkarni RN. Diabetes, Jan 2014.
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Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young). Ræder H, Vesterhus M, El Ouaamari A, Paulo JA, McAllister FE, Liew CW, Hu J, Kawamori D, Molven A, Gygi SP, Njølstad PR, Kahn CR and Kulkarni RN. PLoS One, Apr 2013.
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Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ and Kulkarni RN. Cell Reports, Feb 2013.
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Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets. Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM and Kulkarni RN. Endocrinology, Oct 2012.
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miR-375 targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D and van Obberghen E. Diabetes, Oct 2008.
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