Publications
Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion
Sohyun Moon, Lamyaa Alsarkhi, Tai-Tu Lin, Ryota Inoue, Azeddine Tahiri, Cecilia Colson, Weikang Cai, Jun Shirakawa, Wei-Jun Qian, Jerry Yingtao Zhao and Abdelfattah El Ouaamari. FASEB J. 2023 Oct;37(10):e23185. doi: 10.1096/fj.202300941R. PubMed» Read PDF»
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
Teresa L Mastracci, Minoti Apte, Laufey T Amundadottir, Alexandra Alvarsson, Steven Artandi, Melena D Bellin, Ernesto Bernal-Mizrachi, Alejandro Caicedo, Martha Campbell-Thompson, Zobeida Cruz-Monserrate, Abdelfattah El Ouaamari, Kyle J Gaulton, Andrea Geisz, Mark O Goodarzi, Manami Hara, Rebecca L Hull-Meichle, Alexander Kleger, Alison P Klein, Janel L Kopp, Rohit N Kulkarni, Mandar D Muzumdar, Anjaparavanda P Naren, Scott A Oakes, Søren S Olesen, Edward A Phelps, Alvin C Powers, Cherie L Stabler, Temel Tirkes, David C Whitcomb, Dhiraj Yadav, Jing Yong, Norann A Zaghloul, Maike Sander and Stephen J Pandol. Pancreas. 2022 Oct 1;51(9):1061-1073. doi: 10.1097/MPA.0000000000002170. PMID: 37078927. PubMed» Read PDF»
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
Teresa L Mastracci, Minoti Apte, Laufey T Amundadottir, Alexandra Alvarsson, Steven Artandi, Melena D Bellin, Ernesto Bernal-Mizrachi, Alejandro Caicedo, Martha Campbell-Thompson, Zobeida Cruz-Monserrate, Abdelfattah El Ouaamari, Kyle J Gaulton, Andrea Geisz, Mark O Goodarzi, Manami Hara, Rebecca L Hull-Meichle, Alexander Kleger, Alison P Klein, Janel L Kopp, Rohit N Kulkarni, Mandar D Muzumdar, Anjaparavanda P Naren, Scott A Oakes, Søren S Olesen, Edward A Phelps, Alvin C Powers, Cherie L Stabler, Temel Tirkes, David C Whitcomb, Dhiraj Yadav, Jing Yong, Norann A Zaghloul, Stephen J Pandol and Maike Sander. Diabetes. 2023 Apr 1;72(4):433-448. doi: 10.2337/db22-0942. PMID: 36940317. PubMed»
Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake
Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B Wheeler and Zhiping P Pang. Cell & Bioscience. 2022 Oct 29;12(1):178. doi: 10.1186/s13578-022-00914-3. PMID: 36309763. PubMed» Read PDF»
Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue
Erica P Homan, Bruna Brasil Brandao, Samir Softic, Abdelfattah El Ouaamari, Brian T O’Neill, Rohit N Kulkarni, Jason K Kim, C Ronald Kahn. The Journal of Clinical Investigation. 2021 Oct 1;131(19):e143328. doi: 10.1172/JCI143328. PMID: 34428182. PubMed» Read PDF»
Deconstructing the Origins of Sexual Dimorphism in Sensory Modulation of Pancreatic β Cells
Increased β-cell proliferation before immune-cell invasion prevents progression of type 1 diabetes
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Nature Metabolism. 2019 May;1(5):509-518. doi: 10.1038/s42255-019-0061-8. Epub 2019 May 6. PMID: 31423480. PubMed» Read PDF»
Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a cell non-autonomous fashion
El Ouaamari A, O-Sullivan I, Shirakawa J, Basile G, Zhang W, Roger S, Thomou T, Xu S, Qiang G, Liew CW, Kulkarni RN, Unterman TG. The Journal of Biological Chemistry. 2019 Jan 18;294(3):1059-1069. doi: 10.1074/jbc.RA118.006031. Epub 2018 Nov 20. PMID: 30459233. PubMed» Read PDF»
TRPV1 neurons regulate β-cell function in a sex-dependent manner
Joey Bou Karam, Weikang Cai, Rowaida Mohamed, Tianwen Huang, Lingqiong Meng, Erica Paige Homan, Ercument Dirice, C. Ronald Kahn and Abdelfattah El Ouaamari. Molecular Metabolism. 2018 Dec;18:60-67. doi: 10.1016/j.molmet.2018.10.002. Epub 2018 Oct 5. PMID: 30473098. PubMed» Read PDF»
Insulin signaling regulates the FoxM1/PLK1/CENP-A pathway to promote adaptive β-cell proliferation
Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A and Kulkarni RN. Cell Metabolism. 2017 Apr 4;25(4):868-882.e5. doi: 10.1016/j.cmet.2017.02.004. Epub 2017 Mar 9. PMID: 28286049. PubMed» Read PDF»
Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function
Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O’Neill BT and Kahn CR. Diabetes. 2016 Aug;65(8):2201-13. doi: 10.2337/db16-0212. Epub 2016 May 13. PMID: 27207537. PubMed» Read PDF»
Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas
Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS and Maratos-Flier E. PLoS One. 2016 Feb 12;11(2):e0148252. doi: 10.1371/journal.pone.0148252. eCollection 2016. PMID: 26872145. PubMed» Read PDF»
SerpinB1 Promotes Pancreatic β Cell Proliferation
El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O’Donnell E and Kulkarni RN. Cell Metabolism. 2016 Jan 12;23(1):194-205. doi: 10.1016/j.cmet.2015.12.001. Epub 2015 Dec 15. PMID: 26701651. PubMed» Read PDF»
Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes
Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL and Kulkarni RN. Cell Metabolism. 2015 Aug 4;22(2):239-52. doi: 10.1016/j.cmet.2015.07.015. PMID: 26244933. PubMed» Read PDF»
Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics
El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG 2nd, Smith RD, Qian WJ and Kulkarni RN. Journal of Proteome Research. 2015 Aug 7;14(8):3111-3122. doi: 10.1021/acs.jproteome.5b00587. PMID: 26151086. PubMed» Read PDF»
Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid.
Ræder H, McAllister FE, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder MB, Immervoll H, Hoem D, Dimcevski G, Njølstad PR, Molven A, Gygi SP and Kulkarni RN. Diabetes. 2014 Jan;63(1):259-69. doi: 10.2337/db13-1012. Epub 2013 Sep 23. PMID: 24062244. PubMed» Read PDF»
Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young)
Ræder H, Vesterhus M, El Ouaamari A, Paulo JA, McAllister FE, Liew CW, Hu J, Kawamori D, Molven A, Gygi SP, Njølstad PR, Kahn CR and Kulkarni RN. PLoS One. 2013;8(4):e60229. doi: 10.1371/journal.pone.0060229. Epub 2013 Apr 2. PMID: 23565203. PubMed» Read PDF»
Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states
El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ and Kulkarni RN. Cell Reports. 2013 Feb 21;3(2):401-10. doi: 10.1016/j.celrep.2013.01.007. Epub 2013 Jan 31. PMID: 23375376. PubMed» Read PDF»
Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets
Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM and Kulkarni RN. Endocrinology. 2012 Oct;153(10):4593-9. doi: 10.1210/en.2012-1243. Epub 2012 Jul 17. PMID: 22807489. PubMed» Read PDF»
miR-375 targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells
El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D and van Obberghen E. Diabetes. 2008 Oct;57(10):2708-17. doi: 10.2337/db07-1614. Epub 2008 Jun 30. PMID: 18591395. PubMed» Read PDF»
