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Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a cell non-autonomous fashion. El Ouaamari A, O-Sullivan I, Shirakawa J, Basile G, Zhang W, Roger S, Thomou T, Xu S, Qiang G, Liew CW, Kulkarni RN, Unterman TG. The Journal of Biological Chemistry, Nov 2018. Read PDF »

TRPV1 neurons regulate β-cell function in a sex-dependent manner. Joey Bou Karam, Weikang Cai, Rowaida Mohamed, Tianwen Huang, Lingqiong Meng, Erica Paige Homan, Ercument Dirice, C. Ronald Kahn and Abdelfattah El Ouaamari. Molecular Metabolism, Oct 2018. Read PDF »

Insulin signaling regulates the FoxM1/PLK1/CENP-A pathway to promote adaptive β-cell proliferation. Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A and Kulkarni RN. Cell Metabolism, Mar 2017. Read PDF »

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function. Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O’Neill BT and Kahn CR. Diabetes, Aug 2016. Read PDF »

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS and Maratos-Flier E. PLoS One, Feb 2016. Read PDF »

SerpinB1 Promotes Pancreatic β Cell Proliferation. El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O’Donnell E and Kulkarni RN. Cell Metabolism, Jan 2016. Read PDF »

Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL and Kulkarni RN. Cell Metabolism, Aug 2015. Read PDF »

Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG 2nd, Smith RD, Qian WJ and Kulkarni RN. Journal of Proteome Research, Aug 2015. Read PDF »

The Polycomb protein, Bmi1, regulates insulin sensitivity. Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ and Stoffers DA. Molecular Metabolism, Aug 2014. Read PDF »

Soluble factors secreted by T cells promote β-cell proliferation. Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D and Kulkarni RN. Diabetes, Jan 2014. Read PDF »

Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Ræder H, McAllister FE, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder MB, Immervoll H, Hoem D, Dimcevski G, Njølstad PR, Molven A, Gygi SP and Kulkarni RN. Diabetes, Jan 2014. Read PDF »

Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young). Ræder H, Vesterhus M, El Ouaamari A, Paulo JA, McAllister FE, Liew CW, Hu J, Kawamori D, Molven A, Gygi SP, Njølstad PR, Kahn CR and Kulkarni RN. PLoS One, Apr 2013. Read PDF »

Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ and Kulkarni RN. Cell Reports, Feb 2013. Read PDF »

Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets. Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM and Kulkarni RN. Endocrinology, Oct 2012. Read PDF »

miR-375 targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D and van Obberghen E. Diabetes, Oct 2008. Read PDF »

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